Why Choose PrenatalSafe® and What Are Its Advantages?

ADVANTAGES of the PrenatalSafe test;

1. PrenatalSafe® detects conditions that other tests cannot detect, including rare trisomies, segmental chromosomal abnormalities and monogenic disorders (inherited and de novo).
2. A low-risk result greatly reduces the risk but does not eliminate it; routine ultrasounds should still be performed.
3. PrenatalSafe® distinguishes between maternal and fetal DNA, which helps prevent false positives.
4. Among the NIPTs on the market, PrenatalSafe® has the highest published performance.
5. PrenatalSafe® can detect chromosomal abnormalities at a low fetal fraction (<2%).
6. Unlike any non-invasive prenatal test available to date, the PrenatalSafe® test offers a depth of resolution (>50 million reads).
7. The PrenatalSafe® test is performed in an ISO 17025 and ISO 15189 accredited laboratory with more than 20 years of experience in prenatal diagnosis, where more than 200,000 genetic tests are performed per year.
8. The PrenatalSafe® test is recommended by large numbers of gynecologists worldwide.
9. The PrenatalSafe® test is the only NIPT to date that screens the fetus for both genome-wide chromosomal abnormalities and serious genetic disorders in a single test.
10. Unlike other NIPTs on the market, the Prenatalsafe® test provides a free Rh(D) test (RhSafe). (If the mother is Rh(D) negative and the father is Rh(D) positive)
11. The PrenatalSafe® test is suitable for both singleton and twin pregnancies (including vanishing twin) as well as pregnancies achieved with IVF techniques, including gamete donation.
12. PrenatalSafe® also provides genetic counseling in case of a positive result.
13. The PrenatalSafe® test is performed in Italy (Rome or Milan)

PrenatalSafe is SAFE and RELIABLE;

1. It is a non-invasive test and poses no risk to the fetus or the mother. It is a screening test that analyzes circulating fetal DNA from 10+ weeks of gestation.
2. The PrenatalSafe ® test has a sensitivity and specificity of over 99%, with a very low false-positive rate of under 0.1% of cases.
3. PrenatalSafe ® Karyo Plus shows 99.1% of fetal chromosomal aneuploidies present at birth   and achieves a detection rate very similar to the conventional (96.9%) and molecular (99.8%) fetal karyotype obtained with invasive prenatal diagnostic techniques.
4. Comparison with Invasive Prenatal Diagnosis: The PrenatalSafe® 3  and 5 tests make it possible to highlight 71% and 83.1% of the chromosomal anomalies present in pregnancy, respectively. With the PrenatalSafe® Plus test, the detection rate reaches 86%. The PrenatalSafe® Complete test represents the highest level of investigation available. The test makes it possible to detect 95.5% of the chromosomal anomalies detectable in pregnancy (Karyo Plus investigation level), reaching a detection rate very similar to the conventional fetal karyotype (96.9%) obtained with invasive prenatal diagnostic techniques. It is also capable of identifying mutations responsible for serious genetic diseases.

PrenatalSafe is SENSITIVE;

The test's limit of detection (LOD) is determined at a fetal fraction (FF) of 2%. The fetal fraction value is always reported in the reports.  

PRE-TEST AND POST-TEST GENETIC COUNSELING

To explain to patients the purpose of the analysis, the results that can be obtained and what emerges once the examination is completed.

FAST PROCEDURE

Thanks to the recent introduction of the new high-resolution FAST Technology, once the samples reach the laboratory,  the results will be ready in only 3-5 working days.

RHSAFE® TEST

A non-invasive prenatal examination that allows the fetal Rh (D) factor to be determined. The RhSafe® test is optional and is performed free of charge (on request) in Rh (D) negative pregnant women.

FREE FOLLOW-UP OF PATHOLOGICAL RESULTS

Free follow-up of the pathological result with reference gynecologists affiliated with Eurofins Genoma in case of a positive result for the presence of aneuploidy, structural chromosomal anomaly or genetic mutation.

SAMPLE COLLECTION AND TRANSPORT KIT

Certification according to UN3373 and free shipping of biological samples to our laboratories

ALL-INCLUSIVE CUSTOMER SUPPORT

From sample shipment to reporting, information on sample collection and storage methods.

DEDICATED AND SCIENTIFIC SUPPORT

Qualified molecular biologists and geneticists are always ready to help our patients interpret the results.