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What Is Fertiscan?

FertiScan® is a group of tests that investigate genetic changes associated with female and male infertility. The relevant genes are examined by Next-Generation Sequencing (NGS).

The test can help explain the cause of infertility, plan assisted reproductive treatment and evaluate possible hereditary risks. Approximately 10-15% of male infertility cases and approximately 8-10% of female infertility cases may be associated with genetic changes. Chromosomal abnormalities and Y chromosome microdeletions are not detected by an NGS panel; if the sperm count is below 5 million/mL, karyotyping and Y microdeletion (AZF) testing should be performed first.

Who Can It Be Recommended For?

  • ✓ Couples having difficulty conceiving
  • ✓ Those with unexplained infertility
  • ✓ Those with repeated insemination or IVF failure
  • ✓ Those with recurrent pregnancy loss
  • ✓ Women diagnosed with premature ovarian insufficiency or low ovarian reserve
  • ✓ Those with problems in oocyte maturation or embryo development
  • ✓ Men with azoospermia, oligospermia, or sperm motility or morphology disorders
  • ✓ Those with a family history of infertility or early menopause
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How Is the Test Performed?

Approximately a 3 mL blood sample is taken. After DNA is obtained, the coding regions of the relevant genes are analyzed by NGS. This panel cannot detect the FMR1 CGG repeat expansion; a separate PCR-based repeat analysis is required for Fragile X.

The turnaround time is approximately 15-20 working days.

What Do the Results Mean?

A positive result may indicate that a genetic change associated with infertility has been detected, and it may influence the treatment plan, the tests to be performed on the partner, or the need for genetic counseling.

A negative result indicates that no explanatory change was found in the genes examined; however, it does not rule out all genetic and non-genetic causes of infertility.

FertiScan does not replace hormone tests, ultrasound, semen analysis, karyotyping and other infertility investigations. Results should be evaluated together with clinical findings.
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